Joint Care Plus is designed to enhance the efficacy of your current joint supplement (ie: glucosamine), as part of a more complete nutraceutical regimen for joint health, by delivering the following unique nutraceuticals:
Collagen Type II is a naturally occurring source of the most bioavailable and researched nutraceuticals for joint health: hyaluronic acid, chondroitin and glucosamine. These important biomolecules are major components of hyaline joint cartilage, the delicate, clear, glass-like tissue that protects bone and is found in most joints. We source our collagen from patented KollaGen II-xsTM, which is the result of more than a quarter of a century of collagen food supplement research and boast published clinical studies proving efficacy. KollaGen II-xs was found to be safe and effective in treating joint inflammation, secondary mobility, as well as providing other beneficial effects, according to a 60 day human clinical study. Another study published in a peer-reviewed journal found that 78% percent of the individuals treated noticed substantial improvement in relief of symptoms, including range of motion, pain and muscle strength. 
Hyaluronic acid acts as a cushion and lubricant in joints and other tissues. It also has been shown to affect the way the body responds to injury. Many human indications for hyaluronic acid include injections directly into the skin or joints. According to scientific research and double-blind, placebo-controlled studies in humans, hyaluronic acid taken orally has also been shown to be effective for osteoarthritis.
Chondroitin Sulfate is a biomolecule normally found in cartilage around joints in the body. Chondroitin sulfate is naturally derived from animal sources and helps protect cartilage in joints from breaking down. Chondroitin sulfate is one of the building blocks of cartilage and has been reported to reduce joint damage and slow disease progression in osteoarthritis, through peer-reviewed scientific research.    
In the trial, researchers selected 20 patients’ ages 17 years to 81 years (10 males / 10 females) with confirmed joint damage and cartilage injuries, diagnosed with imaging/scoping with low to high pain scales. Supplementation with KollaGen II-xs produced a significant treatment response at seven days for flexibility (33.3% increase; P = 0.035) and at 60 days for general pain (91.6% reduction; P = 0.005), flexibility (68.5% increase; P = 0.004) and range of motion associated pain (76.1% reduction; P = 0.011). The substantial treatment response continued through 60 days for pain (78.8% reduction; P = 0.001). There were no adverse events reported during the study and the treatment was reported to be well tolerated by study participants. It was concluded that KollaGen II-xs benefited joint inflammation and pain, flexibility, as well as supported arthritic participants (rheumatoid and osteoarthritis alike).
Another study, entitled “A 30-day clinical investigation of the efficacy of KollaGen II-xs, a new avian sternal collagen type II hydrolysate,” was recently published in the peer-reviewed journal HealthMED. The results of the study indicate that the administration of 1500mg of avian sternal collagen type II hydrolysate daily ingested over 30 days is safe and efficacious in reducing symptoms of joint discomfort.
Oe M, Tashiro T, Yoshida H, et al. Oral hyaluronan relieves knee pain: a review. Nutrition Journal. 2016;15:11. doi:10.1186/s12937-016-0128-2.
Uebelhart D, Thonar EJ, Delmas PD, Chantraine A, Vignon E. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthritis Cartilage, 6 (Suppl. A), 39–46 (1998).
Uebelhart D, Malaise M, Marcolongo R, DeVathaire F, Piperno M, Mailleux E, Fioravanti A, Matoso L, Vignon E. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cartilage, 12, 269–276 (2004).
 Michel BA, Stucki G, Frey D, De Vathaire F, Vignon E, Bruehlmann P, Uebelhart D. Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial. Arthritis Rheum., 52, 779–786 (2005).
Kahan A, Uebelhart D, De Vathaire F, Delmas PD, Reginster JY. Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a twoyear, randomized, double-blind, placebo-controlled trial. Arthritis Rheum., 60, 524–533 (2009).